Pushing the Boundaries of Addiction Science
The lab conducts theory-driven, methodologically rigorous research on addiction, integrating experimental paradigms with advanced statistical modeling and multimodal neuroimaging to investigate the neurobehavioral mechanisms underlying substance use and relapse.
Individual differences in genetic, neurobiological, and psychosocial vulnerability interact with environmental exposures to determine susceptibility to addiction.
Drugs of abuse induce acute and chronic neuroadaptations in reward, salience, and cognitive control circuits that alter motivation and behavior.
Persistent dysregulation of motivational and executive systems, coupled with conditioned cues and stress reactivity, sustains compulsive use and relapse risk.
This project aims to identify neurobiological and cognitive-behavioral markers of alcohol use disorder (AUD) and evaluate their utility for predicting relapse after treatment. The …
Examining how social exclusion and social inclusion shape neural alcohol cue reactivity, implicit approach tendencies, laboratory alcohol consumption, and 15-day daily drinking as …
Developing and validating a new psychological assessment scale to measure the differential valuation of substance-related rewards versus natural rewards and other non-drug …
Investigating the role of Autonomic Nervous System regulation in shaping sleep quality across the spectrum of alcohol use, from moderate consumption to Alcohol Use Disorder.
Investigating whether individual differences in reward processing deficits contribute to vulnerability to alcohol addiction by increasing susceptibility to incentive salience …
Investigating the Use of TMS in Modulating Brain Responses to Rewards Associated with Alcohol and Natural Rewards
An FCT-funded project investigating the neural and cognitive mechanisms underlying impaired response inhibition in individuals with alcohol and substance use disorders.
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Freeman, C., Radoman, M., Martins, J. S., Lacadie, C., Seo, D., & Sinha, R. (in press). Sex differences in neural stress and alcohol cue related activation and subjective alcohol craving in binge versus light-moderate drinkers. Neuropsychopharmacology.
Gomes, N., Benrós, M. F., Martins, J. S., & Semin, G. R. (2025). Sweating It Out: A Data-Driven Approach Revealing How Sex and Emotions Shape Sweat Production. Biological Psychology.
Dongju, S., Martins, J. S., & Sinha, R. (2024). Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation. Neurobiology of Stress.
Wemm, S. E., Martins, J. S., Fogelman, N., Max, G., & Sinha, R. (2023). Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol & Alcoholism, 1–10.
Choi, J. J., Martins, J. S., Hwang, S., Kim, K., Sinha, R., & Seo, D. (2022). Neural Correlates of Trauma Are Associated with Physical Health Symptoms. Psychiatry Research: Neuroimaging.
Martins, J. S., Fogelman, N., Wemm, S., Hwang, S. & Sinha, R. (2022). Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment. Drug and Alcohol Dependence, 231, 109253.
Martins, J. S., Joyner, K. J., McCarthy, D. M., Morris, D. H., Patrick, C. J., & Bartholow, B.D. (2021). Differential Brain Responses to Alcohol-Related and Natural Rewards is Associated with Alcohol Use and Problems: Evidence for Reward Dysregulation. Addiction Biology, 27(2), e13118.
Hwang, S., Martins, J. S., Douglas, R., Choi, J., Sinha, R., Seo, D. (2021). Irregular Autonomic Modulation Predicts Risky Drinking and Altered Ventromedial Prefrontal Cortex Response to Stress in Alcohol Use Disorder. Alcohol and Alcoholism, 1–9.
Cofresí, U. R., Watts, A. L., Martins, J. S., Wood, P. K., Sher, K. J., Cowan, N., Miyake, A., & Bartholow, B. D. (2021). Acute Effect of Alcohol on Working Memory Updating: A Latent Variable Analysis. Addiction, 116, 3029–3043.
Martin, J. L., Ferreira, J. A., Haase, R. F., Martens, M. P., Coelho, M., Martins, J. S., Jome, L. M., & Santos, E. R. (2020). The Influence of Personality and Drinking Motives on College Student Binge Drinking in the US and Portugal. European Journal of Health Psychology, 27, 30–42.
Von Gunten, C. D., Bartholow, B. D., Martins, J. S. (2020). Inhibition Tasks Are Not Associated with a Variety of Behaviours in College Students. European Journal of Personality, 34, 412–430.
Martins, J. S., Bartholow, B. D, Cooper, M. L., Irving, K. M., & Piasecki, T.M. (2019). Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue-Reactivity Responses. Alcoholism: Clinical & Experimental Research, 43, 1777–1789.
Miller, A. P., Gizer, I. R., Fleming, W. A., Otto, J. M., Deak, J. D., Martins, J. S., & Bartholow, B. D. (2019). Polygenic Liability for Schizophrenia Predicts Shifting-specific Executive Function Deficits and Tobacco Use in a Moderate Drinking Community Sample. Psychiatric Research, 279, 47–54.
Bartholow, B. D., Fleming, K. A., Wood, P. K., Cowan, N., Saults, J. S., Altamirano, L., Miyake, A., Martins, J. S., & Sher, K. J. (2018). Alcohol Effects on Response Inhibition: Variability across Tasks and Individuals. Experimental and Clinical Psychopharmacology, 26, 251–267.
Martins, J. S., Bartholow, B.D, Cooper, M.L., Von Gunten, C., & Wood, P.K. (2018). Associations Between Executive Functioning, Affect-Regulation Drinking Motives, and Alcohol Use and Problems. Psychology of Addictive Behaviors, 32, 16–18.
Couture, M. E., Stewart, S. H., Cooper, M. L., Kuntsche, E., O’Connor, R. M., Mackinnon, S. P., & DRINC Team. (2017). The DRINC Project: Rationale and Protocol for a Cross-National Study of Drinking Motives in Undergraduates. The International Journal of Alcohol and Drug Research, 6, 7–18. Member of the DRINC Team.
Mackinnon, S. P., Couture, M. E., Cooper, M. L., Kuntsche, E., O’Connor, R. M., Stewart, S. H., & DRINC Team. (2017). Cross‐Cultural Comparisons of Drinking Motives in 10 Countries: Data from the DRINC Project. Drug and Alcohol Review, 36, 721–730. Member of the DRINC Team.
Martin, J. L., Ferreira, J. A., Haase, H. F., Martins, J. S., Coelho, M. (2016). Validation of the Drinking Motives Questionnaire-Revised across US and Portuguese College Students. Addictive Behaviors, 60, 58–63.
Cooper, M. L., O’Hara, R. E., & Martins, J. S. (2015). Does Drinking Improve the Quality of Sexual Experience? AIDS and Behavior, 20, 40–51.
Ferreira, J., Martins, J. S., Coelho, M., & Kahler, W. (2014). Validation of Brief Young Adult Alcohol Consequences Questionnaire (B-YAACQ): Portuguese Version. Spanish Journal of Psychology, 17, 1–8.
Martins, J. S., Coelho, M. S., & Ferreira, J. A. (2010). Hábitos de Consumo de Álcool em Estudantes do Ensino Superior Universitário: Alguns Dados Empíricos. Psychologica, 53, 397–411.
NeuroAdx lab welcomes Sara Félix who joins the lab as a Postdoctoral Researcher.
NeuroAdx lab is pleased to announce the expansion of our research team with two new members.
Bruce Bartholow, Ph.D.
The University of Iowa
Rajita Sinha, Ph.D.
Yale University
Jan Theeuwes, Ph.D.
Vrije Universiteit Amsterdam
Mike LePelley, Ph.D.
University of New South Wales
Francesco Versace, Ph.D.
The University of Texas, Houston
Get in touch with our research team
Neuro Adx Laboratory
William James Center for Research
ISPA–Instituto Universitário
Rua Jardim do Tabaco, 34
1149-041 Lisboa
Portugal
Lab Meetings: Mondays 10:00–1:00 PM
Interested in joining our lab? We're always looking for motivated researchers at all levels.
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